Boron Trichloride → HCID 135850854, compound

Participants

Reaction Conditions

Reaction Steps

A 1M solution of BCl3 in CH2Cl2 (1 ml, 1.00 mmol) was added to a solution of intermediate 7.3 (86 mg, 0.207 mmol) in 2 ml of CH2Cl2 at −50° C., and after being stirred at −50° C. for 15 min, the solution was quenched with MeOH, diluted with EtOAc, washed with H2O, sat. NaHCO3, brine, and dried (Na2SO4). Filtration through a 1″ pad of SiO2 and concentration provided 69 mg (100%) of 7.5. MS (ESI) 339.3 (MH+), 337.3 (MH−).

Provenance & Evidence