Bromine → Ethyl 5-[4-(benzyloxy)phenyl]-4-bromo-1-cyclohexyl-1h-pyrazole-3-carboxylate

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Reaction Steps

Bromine (82 μL, 1.61 mmol) was added to pyrazole 1.3 (500 mg, 1.24 mmol) in AcOH (5 ml) at 0° C. and the reaction mixture was stirred at rt for 17 h. Upon concentration, the crude product was purified by SiO2 chromatography (stepwise gradient: 20 to 25% EtOAc/hexanes) to afford 368 mg (62%) of bromide 8.1. MS (ESI) 483.4 (MH+).

Provenance & Evidence