HCID 11188844, compound → HCID 11167562, compound

Participants

Reaction Steps

Acid 8.5 was prepared from 8.4 according to the procedure described above for the preparation acid 2.4. Thus, 8.4 (47 mg, 0.095 mmol) was saponified to yield 45 mg (99%) of 8.5. HRMS (ESI) calc'd for C25H26BrN2O3 481.1127, found 481.1105 (MH+); 1H NMR (300 MHz, CDCl3) δ 7.78 (d, J=16.1,1H), 7.49–7.34 (m, 5H), 7.27 (d, J=8.8, 2H), 7.12 (d, J=8.8, 2H), 6.88 (d, J=16.1, 1H), 5.14 (s, 2H), 4.04–3.96 (m, 1H), 2.00–1.83 (m, 6H), 1.26–1.24 (m, 4H).

Provenance & Evidence