Boron Trichloride → HCID 21058240, compound

HRID 2216529Notes

Reaction equation

C([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[C:19]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:18][C:17](/[CH:26]=[CH:27]/[C:28]([O:30][CH3:31])=[O:29])=[N:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1.B(Cl)(Cl)Cl>>[CH:20]1([C:19]2[N:15]([C:12]3[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=3)[N:16]=[C:17](/[CH:26]=[CH:27]/[C:28]([O:30][CH3:31])=[O:29])[CH:18]=2)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1

Participants

Reactant 2

HCID 25135Boron Trichloride

HCID 11362046HCID 11362046, compound

Product 1

HCID 21058240HCID 21058240, compoundYield 90%

Procedure

According to the procedure for preparation of 3.1, debenzylation of 9.5 (100 mg, 0.240 mmol) with BCl3 (1.20 mmol) to yielded 70 mg (90%) of 9.7. MS (ESI) 653.7 (2MH+); (2M+Na+).

Sources & evidence

ORD record: ord-bc5c006d8c7846b585a31d50b9dd243e
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07112601B2

Reaction notes

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