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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 221653Generated: October 27, 2026

(3-(Oxiran-2-ylmethoxy)phenyl)methanol → 1-(1-(5-(4-Fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)-3-(3-(hydroxymethyl)phenoxy)propan-2-ol

https://huagongshe.com/reaction/221653

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-(Oxiran-2-ylmethoxy)phenyl)methanolHCID 19385010—
Reactant1-(5-(4-Fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)piperidin-4-amineHCID 69040995—
SolventiPrOH DMSOHCID 87082799—
Product1-(1-(5-(4-Fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)-3-(3-(hydroxymethyl)phenoxy)propan-2-olHCID 2493714235%

Reaction Steps

Synthesis followed SP6 (iPrOH:DMSO 1:1, 14 h), using 150 μmol (3-(oxiran-2-ylmethoxy)phenyl)methanol and 1-(5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)piperidin-4-amine to give the title compound with 35% yield upon purification by prep. HPLC (reversed phase).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08207174B2
Source datasetuspto-grants-2012_06
ORD IDord-a53378432fe14bee9ba5dce6c5f76a0d
Source noteuspto-grants-2012_06