2-(Bromomethyl)-4'-chloro-4-methoxy-1,1'-biphenyl → Ethyl (2E)-3-(2-{4-[(4'-chloro-4-methoxy-1,1'-biphenyl-2-yl)methoxy]phenyl}-1-cyclohexyl-1H-imidazol-4-yl)-2-methyl-2-propenoate

Participants

Role	Name	HCID	Charge
Reactant	2-(Bromomethyl)-4'-chloro-4-methoxy-1,1'-biphenyl	HCID 21943338	—
Reactant	Ethyl (2E)-3-{2-[4-(hydroxy)phenyl]-1-cyclohexyl-1H-imidazol-4-yl}-2-methyl-2-propenoate	HCID 136008555	—
Product	Ethyl (2E)-3-(2-{4-[(4'-chloro-4-methoxy-1,1'-biphenyl-2-yl)methoxy]phenyl}-1-cyclohexyl-1H-imidazol-4-yl)-2-methyl-2-propenoate	HCID 11319241	49%

Reaction Steps

According to the procedure for preparation of 4.4, phenol 13.3 (73 mg, 0.206 mmol) was alkylated with (4′-chloro-4-methoxy-1,1′-biphenyl-2-yl)methyl bromide (71 mg, 0.227 mmol), to yield 59 mg (49%) of 13.4. MS (ESI) 585.4 (MH+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07112601B2
Source dataset	uspto-grants-2006_09
ORD ID	ord-0d2057a3c7354570bfbac719983817e8
Source note	uspto-grants-2006_09