2-{[4-(Hydroxymethyl)phenoxy]methyl}oxirane → 1-(4-(Hydroxymethyl)phenoxy)-3-(1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propan-2-ol

Participants

Role	Name	HCID	Charge
Reactant	2-{[4-(Hydroxymethyl)phenoxy]methyl}oxirane	HCID 24823706	—
Reactant	1-(5-Phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-amine	HCID 69041562	—
Product	1-(4-(Hydroxymethyl)phenoxy)-3-(1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propan-2-ol	HCID 24937140	19%

Reaction Steps

Synthesis followed SP6 (4 h), using 120 μmol (4-(oxiran-2-ylmethoxy)phenyl)methanol and 1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-amine to give the title compound with 19% yield upon purification by prep. HPLC (reversed phase).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08207174B2
Source dataset	uspto-grants-2012_06
ORD ID	ord-72ca669110b54433a8ec81f56afbc0a0
Source note	uspto-grants-2012_06