1-(5-Phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-amine → HCID 69045288, compound

Participants

Reaction Steps

Synthesis followed SP6 (3 h), using 430 μmol 2-((2,3-difluoro-4-methoxyphenoxy)methyl)oxirane and 1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-amine to give O-methylated intermediate 1-(2,3-difluoro-4-methoxyphenoxy)-3-(1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propan-2-ol upon purification by prep. TLC (1 mm silica gel, PE/CH2Cl2/MeOH 4:6:1) with 49% yield. Product was obtained by O-demethylation according to SP12 (3 h) with 58% yield (LCMS: detected [M+1]=513.2).

Provenance & Evidence