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HRID221658

反应详情

EQUATION

反应方程式

HRID 221658 的结构方程式

REACTANTS

反应物

3
结构：Cc1cc(C)nc(N2CCC(N)CC2)n1
HCID4778289

1-(4,6-Dimethyl-2-pyrimidinyl)-4-piperidinamine

C11H18N4

结构：O=c1ccccc(-c2cncnc2)c1O
HCID10750517

未命名化合物

结构：O=C(Oc1cccc(OCC2CO2)c1)c1ccccc1
HCID86623599

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(C)nc(N2CCC(NCC(O)COc3cccc(O)c3)CC2)n1
HCID59819896

未命名化合物

收率 14%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O.CS(C)=O
溶剂HCID87082799

未命名化合物

PROCEDURE

实验过程

Synthesis followed SP6 (iPrOH:DMSO 1:1, 120° C., 24 h), using 200 μmol 3-(oxiran-2-ylmethoxy)phenyl benzoate and 1-(4,6-dimethylpyrimidin-2-yl)piperidin-4-amine to give O-benzoylated intermediate, which was directly treated according to SP10. Title product was obtained by purification by prep. HPLC (reversed phase) and prep. TLC (1 mm silica gel, PE/CH2Cl2/MeOH 4:6:1) with 14% yield (LCMS: detected [M+1]=373.2).

WORKUP

后处理

  1. customSynthesis
  2. customto give O-benzoylated intermediate, which
  3. additionwas directly treated