HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2216599Generated: October 25, 2026
Ammonium Sulfate → 4,4-Dimethylpyrrolidine-2-carboxylic acid
https://huagongshe.com/reaction/2216599
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Sulfate | HCID 6097028 | — |
| Reactant | 3-Chloro-5,5-dimethylpiperidin-2-one | HCID 21941379 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4,4-Dimethylpyrrolidine-2-carboxylic acid | HCID 286642 | — |
Reaction Steps
A suspension of 20.4 g (0.13 mol) of 3-chloro-5,5-dimethyl-2-piperidone and 45.2 g (0.14 mol) of Ba(OH)3-8H2O in 252 mL of water was heated in a Parr apparatus at 150° C. for 6 h. Then, 18.6 g (0.14 mol) of ammonium sulphate were added. The precipitate was filtered off, and the solution was concentrated under reduced pressure to dryness. Crude 4,4-dimethylpyrrolidine-2-carboxylic acid was obtained as a white solid (37.5 g). (J. Med. Chem., 20, 1176 (1977), EP 0 447 704 A1, page 17)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07112582B2 |
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| Source dataset | uspto-grants-2006_09 |
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| ORD ID | ord-2bde3c7c81674c85943c311b1610dae4 |
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| Source note | uspto-grants-2006_09 |
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