Sodium borohydride → HCID 11281965, compound

Participants

Reaction Steps

A mixture of 2-{2-[2-(3,5-difluoro-phenyl)-acetylamino]-pentanoylamino}-4-trifluoromethyl-oxazole-5-carboxylic acid ethyl ester (150 mg, 0.31 mmol) and sodium borohydride (150 mg, 3.947 mmol) in 3 ml methanol was stirred at room temperature for 10 min. The mixture was quenched with water and extracted with ethyl acetate. The organic layer was separated, dried and concentrated and the residue was purified by preparative HPLC to give the title compound as a white solid. APCl M+1=436.1.

Provenance & Evidence