Sodium borohydride → HCID 11463158, compound

Participants

Reaction Steps

To a solution of 2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid (5-acetyl-oxazol-2-yl)-amide (130 mg, 0.34 mmol) in a mixture of MeOH (5 ml) and THF (5 mL) was added NaBH4 (130 mg, 3.9 mmol) at room temperature. After stirring for 10 min, the mixture was concentrated to a small volume, quenched with water and extracted with methylene chloride. The organic layer was separated, dried and concentrated to give 131 mg of the title compound as a colorless oil. LC-MS, RT=1.7 min, M+1=382.2, M−1=380.2.

Provenance & Evidence