HCID 9924560, compound → HCID 9927128, compound

HRID 2216638Notes

Reaction equation

HRID 2216638 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[NH:4][C:3]=1/[CH:8]=[C:9]1\[C:10](=[O:26])[N:11]([CH2:18][N:19]2[CH2:24][CH2:23]N(C)[CH2:21][CH2:20]2)[C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.CC1C=C(C)NC=1/C=C1\C(=O)N(CN2CCC[C@H]2CO)C2C\1=CC=CC=2.CC1C=C(C)NC=1/C=C1\C(=O)N(CN2CCC[C@H]2C(O)=O)C2C\1=CC=CC=2.CC1C(C(NCCN(CC)CC)=O)=C(C)NC=1/C=C1\C(=O)N(CN2CCCC2)C2C\1=CC=CC=2.CC1C(C(NCCNCC)=O)=C(C)NC=1/C=C1\C(=O)N(CN2CCCC2)C2C\1=CC=CC=2.CC1C(C(NCC(O)CN2CCOCC2)=O)=C(C)NC=1/C=C1\C(=O)N(CN2CCCC2)C2C\1=CC=CC=2>>[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[NH:4][C:3]=1/[CH:8]=[C:9]1\[C:10](=[O:26])[N:11]([CH2:18][N:19]2[CH2:24][CH2:23][CH2:21][CH2:20]2)[C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2

Participants

7

Reactant 6

HCID 9924560HCID 9924560, compoundHCID 10301000HCID 10301000, compoundHCID 69553785HCID 69553785, compoundHCID 69554362HCID 69554362, compoundHCID 86584749HCID 86584749, compoundHCID 86584750HCID 86584750, compound

Product 1

HCID 9927128HCID 9927128, compound

Procedure

(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)-methylidene]-1-(4-methylpiperazin-1-ylmethyl)-1,3-dihydro-2H-indol-2-one (13); (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)-methylidene]-1-[2(S)-hydroxymethyl-1-pyrrolidinylmethyl)-1,3-dihydro-2H-indol-2-one; (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)-methylidene]-1-[2(S)-carboxy-1-pyrrolidinylmethyl)-1,3-dihydro-2H-indol-2-one; (3Z)-3-{[3,5-dimethyl-4-(2-diethylaminoethylaminocarbonyl)-1H-pyrrol-2-yl]-methylidene}-1-(1-pyrrolidinylmethyl)-1,3-dihydro-2H-indol-2-one; (3Z)-3-{[3,5-dimethyl-4-(2-ethylaminoethylaminocarbonyl)-1H-pyrrol-2-yl]-methylidene}-1-(1-pyrrolidinylmethyl)-1,3-dihydro-2H-indol-2-one; and (3Z)-3-{[3,5-dimethyl-4-(3-morpholin-4-yl-2-hydroxypropylaminocarbonyl)-1H-pyrrol-2-yl]-methylidene}-1-(1-pyrrolidinylmethyl)-1,3-dihydro-2H-indol-2-one; and 1-({(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)-methylidene]-2-oxo-1,3-dihydro-1H-indol-1-yl}methyl)pyridinium chloride (12).

Sources & evidence

ORD record
ord-da9281fa48c746fd89d0a86ba98c9ff6
Source dataset
uspto-grants-2006_09
Patent number
US07112603B2

Reaction notes

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