Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ferrostatin-1 → Ethyl 1-cyclohexyl-2-(4-hydroxyphenyl)benzimidazole-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ferrostatin-1 | HCID 4068248 | — |
| 반응물 | Methyl 4-hydroxybenzimidate hydrochloride | HCID 135889529 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Ethyl 1-cyclohexyl-2-(4-hydroxyphenyl)benzimidazole-5-carboxylate | HCID 135486203 | 72.5% |
반응 단계
Ethyl 3-amino-4-cyclohexylaminobenzoate (130 g) obtained in Example 1, Step 3, and methyl 4-hydroxybenzimidate hydrochloride (139 g) were added to methyl alcohol (1500 ml), and the mixture was refluxed under heating for 4 hr. The reaction mixture was allowed to cool and the precipitated crystals were collected by filtration to give the title compound (131 g, yield 72%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07112600B1 |
| 출처 데이터셋 | uspto-grants-2006_09 |
| ORD ID | ord-902b03e2d48c489aa5e3721e4c8ab64f |
| 출처 메모 | uspto-grants-2006_09 |