Water → HCID 21943916, compound

Participants

Reaction Steps

A solution of 10 g of P2O5 (0.07 mol) in 100 mL of methanesulfonic acid (1.54 mol) was heated at 80° C. under stirring. A mixture of 2,3-dimethylthiophene (0.27 mol, 30 g) and methacrylic acid (0.35 mol) in 20 mL of CH2Cl2 was added and the resulting reaction mixture was stirred at the same temperature for 1.5 h. Then it was poured into a mixture of ice and water and stirred vigorously. The water layer was extracted with CH2Cl2 (3×50 mL), the organic layers were collected, washed with a 10% aqueous solution of sodium carbonate until neutral pH and finally with water. Then the organic phase was isolated, dried over MgSO4, evaporated off to dryness and distilled in vacuo, b.p. 110° C./1 torr. Yield 10 g (20%).

Provenance & Evidence