Dimethylformamide → HCID 58700835, compound

Participants

Reaction Steps

0.375 mol (35 mL) of POCl3 was added at 0° C. to a 0.45 mol (35 mL) of DMF. At the end of the addition, the mixture was allowed to warm to room temperature and stirred for 1 h. Then it was cooled again to 0° C. and carefully treated with 0.15 mol (20.1 g) of phenylacetone. The resulting reaction mixture was stirred at the same temperature for 1 h. Then it was poured into a mixture of ice and water, added of sodium acetate and extracted with CHC3 (3×50 mL). The organic phase was separated, washed with water until neutral pH, dried over MgSO4 and carefully evaporated off to dryness. The residue was distilled in vacuo, b.p. 90–110° C./0.21 torr.

Provenance & Evidence