HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Fluoride → 2-Cyano-3-fluoropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | 3-Chloropyridine-2-carbonitrile | HCID 818258 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2-Cyano-3-fluoropyridine | HCID 7060408 | 50.1% |
Reaction Steps
A solution of 2-cyano-3-chloropyridine (1 g, 7.22 mmol) in 1-methyl-2-pyrrolidinone (25 mL) was treated with potassium fluoride (1.26 g, 21.68 mmol) and heated at reflux for 18 hours. After cooling, the reaction was diluted with ethyl acetate and extracted with water and brine. Silica gel chromatography afforded 442 mg (50%) of 2-cyano-3-fluoropyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112595B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-74d8bdb909044b52997148b22bf39bac |
| Source note | uspto-grants-2006_09 |