Methyl 3-carbamoyl-5-iodobenzoate → Methyl 3-cyano-5-iodobenzoate

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-methoxycarbonyl-5-iodobenzamide (2.5 g, 8.2 mmol) in thionyl chloride (2 mL) was heated for 2 hours at 90° C. The reaction mixture was cooled and concentrated in vacuo. Silica gel chromatography afforded 670 mg (29%) of methyl-3-cyano-5-iodobenzoate, as a white solid.

Provenance & Evidence