HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → HCID 9921081, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 1-(Thiophen-3-yl)ethanone | HCID 15116 | — |
| Reactant | 3-Oxo-3-(thiophen-3-yl)propanenitrile | HCID 2740075 | — |
| Reactant | Sulfur | HCID 5362487 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | HCID 9921081 | HCID 9921081 | 38% |
Reaction Steps
The procedure of Example 1 was followed except that 3-acetylthiophene (Aldrich) was used in place of acetophenone to prepare the corresponding 2-(thiophene-3-carbonyl)acetonitrile (Steps A and B). 2-Butanone (Aldrich), 2-(thiophene-3-carbonyl)acetonitrile, morpholine, and sulfur were reacted according to the procedure of Step C, Example 1, to afford the desired compound. Yield: 38%; IR (KBr) cm−1: 3337, 3229, 3107, 1576, 1427, 1265, 1162, 855, 736, 719; 1H NMR (CDCl3):δ 1.71 (s, 3H), 2.15 (s, 3H), 6.17 (bs, 2H), 7.30 (d, J=2.2 Hz, 2H), 7.63 (t, 1H, J=2 Hz); yellow solid, mp: 122–123° C. (petroleum ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112607B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-4fafd1a51e594d36b1d88acf9b742e12 |
| Source note | uspto-grants-2006_09 |