HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 1H-Imidazol-1-ylphenylmethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Bifonazole | HCID 2378 | — |
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Product | 1H-Imidazol-1-ylphenylmethanone | HCID 66319 | 74.7% |
Reaction Steps
Bifonazole has also been prepared by benzoylation of imidazole with PhCOCl, yielding 74.7% of 1-benzoylimidazole which is subject to react with Gringnard's reactant 4-PhC6H4MgBr followed by a tosylation and subsequent reduction with sodium cyanoborohydride in hexamethylphosphoramide, to yield 68.2% Bifonazole (Es. Patent 539,345).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112681B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-14a305893a92494cbbdb94af5aff3359 |
| Source note | uspto-grants-2006_09 |