Potassium Iodide → HCID 21946005, compound

Participants

Reaction Steps

(±)-5-(1-Bromo-2-methyl-propyl)-2,4-dichloro-pyrimidine (88.7 mg; 0.312 mmol) (from Example 11b supra) was combined with potassium carbonate (47.4 mg; 0.34 mmol), potassium iodide (14.9 mg; 0.09 mmol) and p-anisidine (38.7 mg; 0.31 mmol) (Aldrich) and stirred at room temperature overnight. The reaction mixture was diluted with ethyl acetate and washed with water and then brine. The organic phase with dried over anhydrous sodium sulfate, filtered, and concentrated. Purification by flash chromatography (Biotage 12M; 10:90 to 30:70 ethyl acetate-hexanes gradient) gave (±)-[1-(2,4-dichloro-pyrimidin-5-yl)-2-methyl-propyl]-(4-methoxy-phenyl)-amine. (Yield 17.6 mg; 17.3%).

Provenance & Evidence