1-Acetyl-6-aminoindoline → HCID 9904166, compound

HRID 2217002Notes

Reaction equation

HRID 2217002 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([NH2:13])[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].OC1C=C(N[C:23]2[C:28]3=[CH:29][C:30](C)=[CH:31][N:27]3[N:26]=[CH:25][N:24]=2)C=CC=1C>C(O)(C)C.C(Cl)Cl>[N:26]1[N:27]2[CH:31]=[CH:30][CH:29]=[C:28]2[C:23]([NH:13][C:10]2[CH:11]=[C:12]3[C:7]([CH2:6][CH2:5][N:4]3[C:1](=[O:3])[CH3:2])=[CH:8][CH:9]=2)=[N:24][CH:25]=1

Participants

4

Reactant 2

HCID 2585641-Acetyl-6-aminoindolineHCID 10131256HCID 10131256, compound

Product 1

HCID 9904166HCID 9904166, compoundYield 4%

Reagents, catalysts & solvents 1

HCID 21966342Isopropanol methylene chlorideSolvent

Procedure

Example 10 was prepared as a white solid in 4% yield from Compound A of Example 1 and 1-acetyl-6-aminoindoline as described for Compound B of Example 1, using 10% isopropanol/methylene chloride for extraction, and with purification by chromatography on silica gel with ethyl acetate. (M+H)+=294.

Workup

  1. extractionfor extraction
  2. customwith purification by chromatography on silica gel with ethyl acetate

Sources & evidence

ORD record
ord-7a49550d777e429e914631a4c3554783
Source dataset
uspto-grants-2006_09
Patent number
US07112675B2

Reaction notes

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