Hydrochloric Acid → HCID 10055133, compound

Participants

Reaction Steps

Di(tert-butyl) (1-(3-((4-((5-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1,3-thiazol-2-yl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)piperidin-4-yl)methyl phosphate (6.64 g, 8.6 mmol), in 1,4-dioxane (250 ml) was treated with 4.0 N hydrochloric acid in 1,4-dioxane (15 ml, 60 mmol) at 20° C. for 18 hours. The solid product was collected by suction filtration and washed with i) 1,4-dioxane (100 ml), ii) acetonitrile (100 ml) and iii) diethyl ether (100 ml), Prolonged drying in vacuo yielded the title compound (6.73 g, 98% yield) as a yellow dihydrochloride salt:

Provenance & Evidence