Hydrochloric Acid → HCID 10032356, compound

Participants

Reaction Steps

Di(tert-butyl) ((2S)-1-(3-((4-((5-(2-((3,4-difluorophenyl)amino)-2-oxoethyl)-1,3-thiazol-2-yl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)pyrrolidin-2-yl)methyl phosphate (537 mg, 0.69 mmol) in dioxane (10 ml) was treated with a solution of HCl (4N) in dioxane (1.2 ml) at ambient temperature for 15 hours. The solid was recovered by filtration, washed with dioxane, dried under vacuum at 50° C. to give the title compound (413 mg, 81% yield):

Provenance & Evidence