Hydrochloric Acid → HCID 86603910, compound

Participants

Reaction Steps

Hydrochloric acid (1 ml of a 4.0 N solution in 1,4-dioxane, 4 mmol) was added, dropwise to a solution of di(tert-butyl) (1-(3-((4-((5-(2-((2-fluorophenyl)amino)-2-oxoethyl)-1,3-thiazol-2-yl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)piperidin-4-yl)methyl phosphate (assumed 379 mg, 0.49 mmol) in 1,4-dioxane (15 ml) upon which a light yellow solid precipitated from the reaction mixture. The resulting heterogeneous reaction mixture was stirred for a further 20 hours and the precipitate was filtered and washed with 1,4-dioxane (2×5 ml) then dried under high vacuum for 48 hours to furnish (1-(3-((4-((5-(2-((2-fluorophenyl)amino)-2-oxoethyl)-1,3-thiazol-2yl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)piperidin-4-yl)methyl dihydrogen phosphate bis-hydrochloride as a light yellow solid (302 mg, 84% yield):

Provenance & Evidence