Hydrochloric Acid → HCID 10461881, compound

Participants

Reaction Steps

Di(tert-butyl) ((2R)-1-(3-((4-((5-(2-((2-fluorophenyl)amino)-2-oxoethyl)-1,3-thiazol-2-yl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)pyrrolidin-2-yl)methyl phosphate (310 mg, 0.41 mmol) in 1,4-dioxane (25 ml) was treated with 4.0 N hydrochloric acid in 1,4-dioxane (0.7 ml, 2.86 mmol) at 20° C. for 18 hours. The solid product was collected by suction filtration and washed successively with 1,4-dioxane (50 ml), acetonitrile (50 ml) then diethyl ether (50 ml), dried in vacuo to give the title compound (287 mg, 97% yield) as a yellow dihydrochloride salt:

Provenance & Evidence