Hydrochloric Acid → HCID 9986889, compound

Participants

Reaction Steps

Di(tert-butyl) ((2R)-1-(3-((4-((5-(2-((2,3-difluorophenyl)amino)-2-oxoethyl)-1,3-thiazol-2-yl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)pyrrolidin-2-yl)methyl phosphate (230 mg, 0.296 mmol) in 1,4-dioxane (15 ml) was treated with 4.0 N hydrochloric acid in 1,4-dioxane (0.9 ml, 3.43 mmol) at 20° C. for 18 hours. The solid product was collected by suction filtration, washed with i) 1,4-dioxane (50 ml), ii) acetonitrile (50 ml) and iii) diethyl ether (50 ml) and then dried in vacuo to yield the title compound (166 mg, 72% yield) as a yellow dihydrochloride salt:

Provenance & Evidence