HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrafluoro-m-phenylenediamine dihydrochloride → HCID 10009601, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Reactant | Di(tert-butyl) ((2s)-1-(3-((4-((5-(2-((2,3-difluorophenyl)amino)-2-oxoethyl)-1,3-thiazol-2-yl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)pyrrolidin-2-yl)methyl phosphate | HCID 91231663 | — |
| Product | HCID 10009601 | HCID 10009601 | 102.4% |
Reaction Steps
An analogous reaction to that described in example 32, but starting with di(tert-butyl) ((2S)-1-(3-((4-((5-(2-((2,3-difluorophenyl)amino)-2-oxoethyl)-1,3-thiazol-2-yl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)pyrrolidin-2-yl)methyl phosphate (202 mg, 0.26 mmol) yielded the title compound (177 mg, 88% yield) as a yellow dihydrochloride salt:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07407946B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-ec26cf219c024bfbafab55bb2ddbaa2f |
| Source note | uspto-grants-2008_08 |