Sodium Carbonate → HCID 69255012, compound

Participants

Reaction Steps

Sodium carbonate (300 mg, 2.83 mmol), 2-napthaleneboronic acid (171 mg, 0.99 mmol) and tetrakis(triphenylphosphine)palladium(0) (30 mg) were added to a solution of 9 (517 mg, 0.93 mmol) in ethanol/water/benzene (20/20/20 mL) and stirred at room temperature for 96 hours. The reaction mixture was diluted with ethyl acetate (220 mL) and washed with water (50 mL) and brine (50 mL) and dried over magnesium sulphate. The crude product was purified by flash column chromatography using 70% ethyl acetate in hexane as eluent to give the pure product 10 as a yellow oil.

Provenance & Evidence