反应详情

To a solution of t-butyl 2-amino-thiophene-3-carboxylate (0.6 g) in dry pyridine (20 ml) was added 4-phenoxyphenylisocyanate (0.84 g). The mixture was stirred for 48 h, then the dark coloured solution was poured into water (200 ml). The stirred mixture was acidified with acetic acid and a precipitate slowly solidified to give a brown solid. After about 1 hr, the solid was filtered off, dried in vacuo and recrystallised from acetonitrile, giving an off-white solid. MP=203-205° C. Yield=0.6 g (48.8%).

1. customto give a brown solid
2. waitAfter about 1 hr
3. filtrationthe solid was filtered off
4. customdried in vacuo
5. customrecrystallised from acetonitrile
6. customgiving an off-white solid