Water → 1-(4-Bromophenyl)-2,2,2-trifluoroethanol

Participants

Reaction Steps

To a room temperature solution of commercial 4′-bromo-2,2,2-trifluoroacetophenone (100 mg) in 1.9 mL of methanol was added sodium borohydride (15 mg). The mixture was stirred at room temperature overnight. Water was added, extracted with methyl t-butyl ether (3×20 mL) washed with water and brine. It was dried with magnesium sulfate and the solvent removed under reduced pressure to yield the title compound and it was used as such for the next step.

Provenance & Evidence