HCID 86605162, compound → HCID 59767796, compound

Participants

Reaction Steps

The 1:1 diastereomeric mixture from step 2 in example 9 (80 mg) was dissolved in ethanol (2 mL). The mixture of compounds was resolved in ˜10 injections (10×200 μL) with a Chiralcel OD semi-preparative column (2 cm I.D.×25 cm) eluting with 32.5% 2-propanol in hexanes and a flow rate of 6 mL/min. The fast fractions eluted at 21-23 min were pooled and concentrated to give N1-(1-cyanocyclopropyl)-N2-((1S)-1-{4′-[(1R)-2,2-difluoro-1-hydroxy-1-methylethyl]biphenyl-4-yl}-2,2,2-trifluoroethyl)-4-fluoro-L-leucinamide as a white powder (98% d.e.). Stereochemistry is tentative.

Provenance & Evidence