HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloro-5,6,7,8-tetrahydroquinoxaline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 1,2,5,6,7,8-Hexahydroquinoxalin-2-one | HCID 820224 | — |
| Product | 2-Chloro-5,6,7,8-tetrahydroquinoxaline | HCID 22036934 | 86% |
Reaction Steps
A mixture of 5,6,7,8-tetrahydro-2(1H)-quinoxalinone in phosphoryl chloride (200 ml) was stirred and refluxed for 3 hours. The solvent was evaporated. The residue was taken up in ice and CH2Cl2. The mixture was basified with NH4OH. The organic layer was separated, dried (MgSO4), filtered and the solvent was evaporated, yielding 34 g (86%) of 2-chloro-5,6,7,8-tetrahydroquinoxaline (interm. 3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07407969B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-397cd1b96a6b4be38fc7ecd96ca7ec07 |
| Source note | uspto-grants-2008_08 |