HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2217314Generated: November 1, 2026
Triethylamine → 2-(3-oxo-3H-isobenzofuran-1-ylidenemethyl)-isonicotinonitrile
https://huagongshe.com/reaction/2217314
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Dimethyl (3-oxo-1,3-dihydro-2-benzofuran-1-yl)phosphonate | HCID 11118213 | — |
| Reactant | 2-Formylisonicotinonitrile | HCID 14761468 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(3-oxo-3H-isobenzofuran-1-ylidenemethyl)-isonicotinonitrile | HCID 68610596 | — |
Reaction Steps
To a cooled suspension (ca 0° C.) of [(3-Oxo-1,3-dihydro-isobenzofuran-1-yl)-phosphonic acid dimethyl ester] phosphonate (i) (8.0 g, 33.0 mmol) in THF (400 mL) was added crude 2-formyl-isonicotinonitrile (iid)(30.0 mmol) followed by triethylamine (6.2 mL, 33.0 mmol). The mixture was stirred for 30 minutes at 0° C. and then allowed to warm overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07407957B2 |
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| Source dataset | uspto-grants-2008_08 |
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| ORD ID | ord-2e099d67d20e4ead982c3dcca0e2a104 |
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| Source note | uspto-grants-2008_08 |
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