反应详情

温度

95 °C

A mixture of 1-indanone (6.00 g; 45.4 mmol), thiourea (6.92 g; 90.8 mmol) and iodine (11.52 g; 45.4 mmol) was heated to 95° C. with stirring. After 3 hours, the mixture was allowed to cool to room temperature. The crude solid was triturated with absolute ethanol and filtered. The light yellow solid was washed twice with absolute ethanol then allowed to air dry to provide 9.13 g of 8H-Indeno[1,2-d]thiazol-2-ylamine hydroiodide 1a.

1. temperatureto cool to room temperature
2. customThe crude solid was triturated with absolute ethanol
3. filtrationfiltered
4. washThe light yellow solid was washed twice with absolute ethanol
5. customto air dry