HCID 49796119, compound → 8H-indeno[1,2-d][1,3]thiazol-2-amine

HRID 2217325Notes

Reaction equation

HRID 2217325 reaction equation
I.[S:2]1[C:6]2[CH2:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[C:5]=2[N:4]=[C:3]1[NH2:14]>[OH-].[Na+]>[S:2]1[C:6]2[CH2:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[C:5]=2[N:4]=[C:3]1[NH2:14]

Participants

3

Reactant 1

HCID 49796119HCID 49796119, compound

Product 1

HCID 131876678H-indeno[1,2-d][1,3]thiazol-2-amineYield 97.5%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Indeno[1,2-d]thiazol-2-ylamine hydroiodide 1a (9.13 g) was stirred with 100 mL of 1N sodium hydroxide for 1 hour at room temperature then filtered. The solid was washed with water (3×20 mL) and then allowed to air dry to provide 5.30 g of 8H-Indeno[1,2-d]thiazol-2-ylamine 1b.

Workup

  1. filtrationthen filtered
  2. washThe solid was washed with water (3×20 mL)
  3. customto air dry

Sources & evidence

ORD record
ord-233777f80ca84c7f8c013e36f0aebe40
Source dataset
uspto-grants-2008_08
Patent number
US07407977B2

Reaction notes

Loading…