Iodine → HCID 86602971, compound

HRID 2217334Notes

Reaction equation

HRID 2217334 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=O)[CH2:6][CH2:5]2.[NH2:12][C:13]([NH2:15])=[S:14].[I:16]I>>[IH:16].[Cl:1][C:2]1[CH:10]=[CH:9][C:8]2[C:7]3[N:12]=[C:13]([NH2:15])[S:14][C:6]=3[CH2:5][C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 807IodineHCID 1425995-Chloro-1-indanoneHCID 2723790Thiourea

Product 1

HCID 86602971HCID 86602971, compoundYield 28.5%

Conditions

Temperature
100 °C

Procedure

A mixture of 5-chloro-1-indanone (1.00 g; 6.00 mmol), thiourea (0.917 g; 12.0 mmol) and iodine (1.55 g; 6.10 mmol) was heated to 100° C. in a sealed tube. After 1 hr., the mixture was allowed to cool to room temperature. The solid was triturated with water and filtered. The solid was then triturated with absolute ethanol, filtered and washed several times with absolute ethanol to provide 0.60 g of 6-Chloro-8H-indeno[1,2-d]thiazol-2-ylamine hydroiodide 10.

Workup

  1. temperatureto cool to room temperature
  2. customThe solid was triturated with water
  3. filtrationfiltered
  4. customThe solid was then triturated with absolute ethanol
  5. filtrationfiltered
  6. washwashed several times with absolute ethanol

Sources & evidence

ORD record
ord-325921e80a0b4f53a57bffd44ad4cb1c
Source dataset
uspto-grants-2008_08
Patent number
US07407977B2

Reaction notes

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