8H-indeno[1,2-d][1,3]thiazol-2-amine → HCID 11572744, compound

HRID 2217336Notes

Reaction equation

HRID 2217336 reaction equation
[S:1]1[C:5]2[CH2:6][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[C:4]=2[N:3]=[C:2]1[NH2:13].[NH:14]1[CH:18]=[C:17]([C:19](Cl)=[O:20])[CH:16]=[N:15]1>>[S:1]1[C:5]2[CH2:6][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[C:4]=2[N:3]=[C:2]1[NH:13][C:19]([C:17]1[CH:18]=[N:14][NH:15][CH:16]=1)=[O:20]

Participants

3

Reactant 2

HCID 131876678H-indeno[1,2-d][1,3]thiazol-2-amineHCID 22228227HCID 22228227, compound

Product 1

HCID 11572744HCID 11572744, compoundYield 42.1%

Procedure

Acylation 8H-Indeno[1,2-d]thiazol-2-ylamine 1b (Prepared in Example 1, Step 2, 377 mg; 2.00 mmol) with 4-pyrazolecarbonyl chloride 12 (208 mg; 1.6 mmol) in a manner similar to that described in Example 7, provided 190 mg of 1H-Pyrazole-4-carboxylic acid (8H-indeno[1,2-d]thiazol-2-yl)-amide 13 as a dark powder.

Sources & evidence

ORD record
ord-6f099a763e004a528ea361f85f66c7cb
Source dataset
uspto-grants-2008_08
Patent number
US07407977B2

Reaction notes

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