Iodine → HCID 49796118, compound

HRID 2217337Notes

Reaction equation

HRID 2217337 reaction equation
[C:1]1(=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[NH2:12][C:13]([NH2:15])=[S:14].[I:16]I>O>[IH:16].[N:12]1[C:1]2[C:10]3[C:5]([CH2:4][CH2:3][C:2]=2[S:14][C:13]=1[NH2:15])=[CH:6][CH:7]=[CH:8][CH:9]=3

Participants

5

Reactant 3

HCID 807IodineHCID 107241-TetraloneHCID 2723790Thiourea

Product 1

HCID 49796118HCID 49796118, compoundYield 32.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
95 °C

Procedure

A mixture of 1-tetralone (5.00 mL; 37.6 mmol), thiourea (5.72 g; 75.2 mmol) and iodine (9.54 g; 37.6 mmol) were heated to 95° C. with stirring. After 4 hr., the mixture solidified and was allowed to cool to room temperature. The mixture was diluted with 200 mL of water and the solid material was filtered off and triturated with absolute ethanol. The solid was washed several times with absolute ethanol to provide 4.00 g of 4,5-Dihydro-naphtho[1,2-d]thiazol-2-ylamine hydroiodide 15 as an off white powder.

Workup

  1. temperatureto cool to room temperature
  2. filtrationthe solid material was filtered off
  3. customtriturated with absolute ethanol
  4. washThe solid was washed several times with absolute ethanol

Sources & evidence

ORD record
ord-8400d2858c2a4accad689fb42cc8935b
Source dataset
uspto-grants-2008_08
Patent number
US07407977B2

Reaction notes

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