Iodine → HCID 10172205, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-benzosuberone (1.00 mL; 6.7 mmol), thiourea (1.02 g; 13.4 mmol) and iodine (1.70 g; 6.7 mmol) were heated to 95° C. with stirring. After 20 hr., the mixture was allowed to cool to room temperature, diluted with 200 mL of water, the solid material filtered off washed twice with 25 mL of water followed by diethyl ether (3×20 mL) to provide 1.50 g of 5,6-Dihydro-4H-3-thia-1-aza-benzo[e]azulen-2-ylamine hydroiodide 17 as an off white powder.

Provenance & Evidence