反应详情

温度

95 °C

A mixture of 4-chromanone (2.00 g; 13.5 mmol), thiourea (2.06 g; 27.0 mmol) and iodine (3.43 g; 13.5 mmol) were heated to 95° C. with stirring. After 4.5 hr., the mixture was allowed to cool to room temperature, triturated with methylene chloride, the solid material filtered off. The solid was further triturated with ethyl acetate, filtered and washed with ethyl acetate to provide 3.00 g of 4H-Chromeno[4,3-d]thiazol-2-ylamine hydroiodide 19 as an off white powder.

1. temperatureto cool to room temperature
2. customtriturated with methylene chloride
3. filtrationthe solid material filtered off
4. customThe solid was further triturated with ethyl acetate
5. filtrationfiltered
6. washwashed with ethyl acetate