HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2217381Generated: November 2, 2026
Sodium Hydroxide → 4-Aminomethyl-1-N-Cbz-piperidine
https://huagongshe.com/reaction/2217381
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 131726983 | HCID 131726983 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Aminomethyl-1-N-Cbz-piperidine | HCID 21955499 | — |
Reaction Steps
27.5 g (79.88 mmol) 4-(trifluoroacetyl-aminomethyl)-N(benzyloxycarbonyl)-piperidine are dissolved in 150 ml dioxane and 150 ml 1 N NaOH solution are added. The mixture is stirred for 3 hours at 40° C. and then the solvent is concentrated under vacuum. The residue is collected in water and extracted three times with DCM. The combined DCM phases are dried over Na2SO4 and then the solvent is concentrated under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07407982B2 |
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| Source dataset | uspto-grants-2008_08 |
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| ORD ID | ord-5f5ca3ded35140819df595a4ac9b532a |
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| Source note | uspto-grants-2008_08 |
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