HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (2R, 4R)-4-Methoxy-pyrrolidine-2-carboxylic acid [2-fluoro-4-(2-oxo-piperidin-1-yl)-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2R,4R)-2-[2-Fluoro-4-(2-oxo-piperidin-1-yl)-phenylcarbamoyl]-4-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 11154790 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2R, 4R)-4-Methoxy-pyrrolidine-2-carboxylic acid [2-fluoro-4-(2-oxo-piperidin-1-yl)-phenyl]-amide | HCID 11416392 | — |
Reaction Steps
Into a solution of 8 (0.329 g, 0.761 mmol) in anhydrous CH2Cl2 (5 mL) was added TFA (5 mL). The solution was stirred at RT for 0.5 h before concentrating under reduced pressure to reveal 9 (0.255 g, 100%) as a tan oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07407972B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-0f7bd9a2ae9049aba23ddafd5860c802 |
| Source note | uspto-grants-2008_08 |