HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2217491Generated: November 1, 2026
Ethyl diazoacetate → 5-(3-Fluoro-2'-methanesulfonyl-biphenyl-4-ylcarbamoyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester
https://huagongshe.com/reaction/2217491
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl diazoacetate | HCID 12192 | — |
| Reactant | N-(3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-acrylamide | HCID 22181505 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-(3-Fluoro-2'-methanesulfonyl-biphenyl-4-ylcarbamoyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester | HCID 68805340 | — |
Reaction Steps
To N-(3-Fluoro-2′-methanesulfonyl-biphenyl-4-yl)-acrylamide (4.47 g) in ethyl acetate (150 ml) was added ethyl diazoacetate (1.5 equiv.) and the mixture heated at 60° C. for 24 hours. Evaporated and then columned: eluant 10-100 EtOAc in hexane. Collected 5-(3-fluoro-2′-methanesulfonyl-biphenyl-4-ylcarbamoyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester (1.67 g)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07407972B2 |
|---|
| Source dataset | uspto-grants-2008_08 |
|---|
| ORD ID | ord-fab0218742c54b728b07e5354369c2d4 |
|---|
| Source note | uspto-grants-2008_08 |
|---|
