Hydrochloric Acid → HCID 19927436, compound

Participants

Reaction Steps

2.8 g of 3,7-dihydroxy-phthalide (see Examples 105 and 106) are introduced into a solution of 7.5 g of potassium cyanide in 35 ml of water, and 25 ml of concentrated hydrochloric acid are slowly added to the mixture while cooling with ice, so that the internal temperature does not exceed 10° C. The reaction mixture is maintained at room temperature for a further 5 hours and then the crystals are filtered off. Having been washed with water and dried well, the product (m.p. 213°-215° C.) is pure 4-hydroxy-1,3-dihydro-3-oxo-1-isobenzofurancarboxamide.

Provenance & Evidence