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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2217528Generated: October 31, 2026

HCID 68805308, compound → N-(4-Cyanophenyl)pyrrolidine-2-carboxamide

https://huagongshe.com/reaction/2217528

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 68805308HCID 68805308—
SolventDichloromethaneHCID 6344—
SolventTrifluoroacetic acidHCID 6422—
ProductN-(4-Cyanophenyl)pyrrolidine-2-carboxamideHCID 12378874—

Reaction Steps

2-(4-Cyano-phenylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (3 g, 8 mmol) was dissolved in 90 mL of a 1:2 mixture of trifluoroacetic acid and dichloromethane. The reaction was stirred at ambient temperature for one hour then concentrated to yield title compound as an amber oil which was carried onto next step as is. APCI (AP−): 214.1 (M−H)−.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07407974B2
Source datasetuspto-grants-2008_08
ORD IDord-639a2ad4099a4382835ae2095399f5c6
Source noteuspto-grants-2008_08