HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → (2R,4R)-Methyl 4-methoxypyrrolidine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2R,4R)-4-Methoxy-1-trityl-pyrrolidine-2-carboxylic acid methyl ester | HCID 68806999 | — |
| Solvent | Water | HCID 962 | — |
| Product | (2R,4R)-Methyl 4-methoxypyrrolidine-2-carboxylate | HCID 28937962 | — |
Reaction Steps
To a flask containing 3 (4.67 g, 11.6 mmol) was added a solution of CH2Cl2 (27 mL), water (0.3 mL), and TFA (3.0 mL, 38.9 mmol). The solution was stirred at RT for 3 h before concentrating under reduced pressure to reveal impure 4. MS: APCI (AP+): 160.1 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07407974B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-6b15907fb0eb4613ad2b1f357588c084 |
| Source note | uspto-grants-2008_08 |