HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (2R,4R)-4-[(4-Methoxy-pyrrolidine-2-carbonyl)-amino]-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2R,4R)-4-Methoxy-2-(4-methoxycarbonyl-phenylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 68808041 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2R,4R)-4-[(4-Methoxy-pyrrolidine-2-carbonyl)-amino]-benzoic acid methyl ester | HCID 68815558 | 100.1% |
Reaction Steps
Into a solution of 7 (12.5 g, 33.0 mmol) in anhydrous CH2Cl2 (70 mL) was added TFA (20 mL). The solution was stirred at RT overnight before concentrating under reduced pressure to give 8 (9.19 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07407974B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-9432a9e6745845d9a3147a3ecbe6fb60 |
| Source note | uspto-grants-2008_08 |