Boron tribromide → 3,7-Dihydroxy-3-trifluromethyl-phthalide

HRID 22176Notes

Reaction equation

[OH:1][C:2]1([C:14]([F:17])([F:16])[F:15])[C:11]2[C:6](=[C:7]([O:12]C)[CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[O:3]1.B(Br)(Br)Br>>[OH:1][C:2]1([C:14]([F:16])([F:15])[F:17])[C:11]2[C:6](=[C:7]([OH:12])[CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[O:3]1

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 199274713-Hydroxy-7-methoxy-3-trifluoromethyl-phthalide

Product 1

HCID 199274693,7-Dihydroxy-3-trifluromethyl-phthalide

Procedure

The title compound can be prepared analogously to the above Example (133) from 3-hydroxy-7-methoxy-3-trifluoromethyl-phthalide (see Example 133 ) and boron tribromide; m.p. 128°-129° C.

Sources & evidence

ORD record: ord-fb0a297d47fb4ba18ad17e151d19c5dc
Source dataset: uspto-grants-1995_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05428002

Reaction notes

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