Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 123022-35-5 | HCID 14053117 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 11558627 | HCID 11558627 | — |
Reaction Steps
5-(4-Hydroxy-3-methoxyphenyl)-penta-2E,4E-dienoic acid (110 mg, 0.5 mmol) [Example 3] was dissolved in 100 mL of DMF. Triethylamine (101 μl, 1.0 mmol) was added, the mixture was cooled down to 0° C. and a solution of benzylamine (109 μl, 1.0 mmol) was added followed by addition of BOP reagent (331 mg, 0.75 mmol) in 50 mL of dichloromethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07407989B2 |
|---|
| Source dataset | uspto-grants-2008_08 |
|---|
| ORD ID | ord-66f4b461929f409996fe189d6725a13e |
|---|
| Source note | uspto-grants-2008_08 |
|---|
